CDC Recommends Four COVID-19 Shots for Immunocompromised People

CDC Recommends Four COVID-19 Shots for Immunocompromised People

On Oct. 25, 2021, the U.S. Centers for Disease Control and Prevention (CDC) updated its COVID-19 vaccine guidance for moderately to severely immunocompromised people over the age of 18 years to include a total of four doses of a COVID-19 biologic.1

Moderate to Severely Immune Compromised People Can Get A Fourth COVID Shot Six Months After Primary Series

The CDC’s new guidance states that moderately to severely immunocompromised people can receive a COVID booster shot at least six months after getting the primary vaccine series, which for the immunocompromised consists of three doses.2

COVID biologic dosing/series is different for immunocompromised individuals than for the general population. In August 2021, the CDC recommended that immunocompromised people who received the two dose series of either the experimental Pfizer/BioNTech or Moderna/NIAID mRNA biologics should also get a third dose of an mRNA biologic.3 4

Federal guidelines stipulated the third dose should be from the same vaccine manufacturer as the first two administered doses.5 The third dose was also not considered to be a booster shot but an extra dose that is part of the primary vaccine series for immunocompromised people.6

The CDC recommendations for the immunocompromised are also different for the Johnson & Johnson COVID vaccine. Moderately or severely immunocompromised people who received a single dose Johnson & Johnson COVID vaccine primary series are recommended to get a single COVID booster shot (Pfizer/BioNTech, Moderna/NIAID or Johnson & Johnson) at least two months after receiving their initial Johnson & Johnson primary dose.7

Significant Numbers of COVID Breakthrough Cases Are in Vaccinated Immunocompromised People

The CDC has said that data from small studies have shown that fully vaccinated immunocompromised people have accounted for a large proportion of hospitalized breakthrough cases.8 In a U.S study, 44 percent of hospitalized breakthrough cases occurred in immunocompromised people, while in an Israeli 9, 40 percent of hospitalized breakthrough cases occurred in immunocompromised patients.

Immunocompromised people infected with the SARS CoV-2 virus are also more likely to transmit the virus to household contacts.1

Immunocompromised People Fail to Mount an Immune Response After Two COVID-19 Shots

Public health officials have said that immunocompromised people do not mount an adequate immune response after receiving two doses of COVID vaccine, which is why they need a third dose.10

Scientists at John Hopkins University conducted a small study published in the Annals of Internal Medicine with a sample of 30 organ transplant patients, who had been fully vaccinated with two doses of a messenger RNA (mRNA) biologic. Since organ transplant patients take immune suppressing medications to ensure that their body does not reject the transplant, there was concern that they may not be mounting a robust immune response to the COVID vaccine.11

After examining COVID vaccine antibody levels following two doses, scientists found that 24 vaccinated patients had no antibodies against the SARS-CoV-2 virus and six of the patients had very low levels of antibodies.11

The organ transplant patients were then given a third dose of either the Pfizer/BioNTech, Moderna/NIAID or Johnson & Johnson COVID-19 shots. Their antibody levels were tested again two weeks following the administration of the third dose. The findings showed that there was an increase in antibody levels in eight of the patients who had no antibodies after two doses, while six patients, who started off with low levels after two doses, had an increase in antibodies against the SARS-CoV-2 virus.12

The scientists who conducted the study commented on the limitations of the study said:

Limitations of this study include a small and heterogeneous convenience sample and the absence of assays for neutralizing antibody, B-cell memory, and T-cell responses.13

Although only one-third of vaccinated patients, who had not responded to two doses of the COVID shot developed antibodies after the third dose, John Wherry, PhD, director of the institute of immunology at the University of Pennsylvania said:

This is a glass half full versus glass half empty kind of thing. One third is not zero, so it does offer some promise for people that are on immunosuppressant drugs.14

Only Certain Immunocompromised People are Eligible for the Fourth COVID Shot

  The CDC states that third and fourth doses of a COVID shot are only recommended for immunocompromised people undergoing organ transplants, are actively receiving treatment for cancer, have advanced HIV infections, or are taking chronic immune suppressing medications.15


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Click here to view References:

1 U.S. Centers for Disease Control and Prevention. Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States. Oct. 25, 2021.
2 Lewis R. Some immunocompromised people can receive a 4th Covid shot, CDC says. NBC News Oct. 27, 2021.
3 Ibid.
4 Edwards E.  CDC advisory group recommends extra shot for immunocompromised patients. NBC News Aug. 13, 2021.
5 Ibid.
6 Lewis R. Some immunocompromised people can receive a 4th Covid shot, CDC says. NBC News Oct. 27, 2021.
7 CDC. Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States. Oct. 25, 2021.
8 CDC. Media Statement from CDC Director Rochelle P. Walensky, MD, MPH, on Signing the Advisory Committee on Immunization Practices’ Recommendation for an Additional Dose of an mRNA COVID-19 Vaccine in Moderately to Severely Immunocompromised People. Aug. 13, 2021.
9 Oliver S. Data and clinical considerations for additional doses inimmunocompromised people. CDC July 22, 2021.
10 Syal A, Edwards E. A third dose of Covid vaccine may help protect immunocompromised patients, small study suggests. NBC News June 14, 2021.
11 Ibid.
12 Ibid.
13 Werbel W, et al. Safety and Immunogenicity of a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series. Annals of Internal Medicine 2021; 174(9): 1330-1332.
14 Syal A, Edwards E. A third dose of Covid vaccine may help protect immunocompromised patients, small study suggests. NBC News June 14, 2021.  
15 Citroner G. Here’s Who May Need a Fourth COVID-19 Vaccine Dose. Healthline Oct. 28, 2021.

8 Responses to "CDC Recommends Four COVID-19 Shots for Immunocompromised People"

  1. Larry Lynn Potter   November 8, 2021 at 3:40 pm

    What a line of BS, No wonder people don’t want to get the shot in the first place, it doesn’t work.

    Reply
  2. Austin1904   November 8, 2021 at 4:24 pm

    With an understanding that the “jab” completely destroys one’s immune system, and more so with each successive “jab”….I’d love to get the real numbers of antibodies of these poor schlubs 4 weeks…..6 weeks….10 weeks afterward. I guess they’ll just keep pumping this crap into them until they get the result they’re looking for.

    Reply
  3. ellie   November 8, 2021 at 5:14 pm

    The result they want is one less useless feeder. (Kissinger)

    The sicker people are, the less toxins they should have barbarically injected into their body! We are divinely designed. Sickness comes from too much of the bad stuff and not enough of the good stuff. The Germ Theory is a theory — NEVER proven! NEVER! ZERO vaccines have been proven safe and effective. ZERO!!

    Reply
    • Jeanne   November 9, 2021 at 12:57 pm

      So true!!!

      Reply
  4. Tom   November 8, 2021 at 5:21 pm

    The only absolute thing that 4 mRNA gene therapy injections are going to do is kill you faster.

    Reply
  5. Dave   November 8, 2021 at 6:15 pm

    Not clear to me how ANYONE can still “trust the science” after how the pharmaceutical industrial complex has so distorted what the word science means. When is it going to become obvious to the sleeping ‘Rip Van Winkles’ amongst us! I keep thinking, OK, they have finally gone too far, and alarm bells are going off for the masses, but nope, there is still more room for their agenda to survive.

    Reply
  6. Donna Roeder   November 8, 2021 at 8:03 pm

    If they can’t kill us with 1, keep trying.

    Reply
  7. Ron S   November 12, 2021 at 7:50 pm

    We shouldn’t give vaccine if they don’t work.

    Reply

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