‘COVID-19 Rebound’ May Be Worse Than Initial COVID Illness

‘COVID-19 Rebound’ May Be Worse Than Initial COVID Illness

On May 24, 2022, the U.S. Centers for Disease Control and Prevention (CDC) issued a health advisory to health care providers, public health departments and the general public regarding Pfizer’s antiviral drug Paxlovid, designed to treat symptoms of COVID-19. The advisory warns that some people who take Paxlovid may experience a recurrence of COVID symptoms two to eight days after completing the five-day course (three pills twice a day) of the drug.1 2 3

The CDC calls this COVID disease recurrence “COVID-19 rebound,” although the phenomenon has also been referred to as “Paxlovid rebound.”1 2 3 4

Paxlovid was given Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration (FDA) on Dec. 21, 2021. It consists of nirmatrelvir tablets (produced by Pfizer) and ritonavir tablets (produced by AbbVie), “co-packaged for oral use.” According to an article in Managed Healthcare Executive last month, nirmatrelvir “acts directly on the SARS-CoV virus” and ritonavir, which is a “repurposed” HIV/AIDS drug, “boosts the effectiveness of nirmatrelvir.”1 4 5 7

Some patients who develop COVID-19 rebound have “milder COVID symptoms than they originally had and others have the same or worse symptoms, while remaining contagious and able to spread the SARS-CoV-2 virus to others, wrote Carolyn Hendler in a recent article in The Vaccine Reaction.1

Hendler noted that Pfizer claims Paxlovid is 87-89 percent effective at “preventing a 28-day hospitalization stay or death” for COVID patients.1 She added:

However, in a growing number of patients these effects appear temporary with patients initially feeling better and some even testing negative upon completion of the five-day course only to have a resurgence of symptoms and a positive test about a week later. Some patients only have a positive test without having symptoms while others have the same or worse symptoms as their original bout with COVID.1

“Paxlovid rebound is real and poorly understood,” says Bob Wachter, MD, chairman of the Department of Medicine at the University of California, San Francisco (UCSF). “We need urgent study and patient counseling.”4

No Evidence Second Round of Paxlovid Helps

It is unclear whether people who have taken Paxlovid and come down with COVID-19 rebound should take a second round of Paxlovid tablets, although a second round of the drug is allowed under its EUA status. Both the FDA and CDC have said there is no evidence to indicate that repeated treatments with Paxlovid offer any benefit.3 4 5

The FDA states:

[T]here is no evidence of benefit at this time for a longer course of treatment (e.g., 10 days rather than the 5 days recommended in the Provider Fact Sheet for Paxlovid) or repeating a treatment course of Paxlovid in patients with recurrent COVID-19 symptoms following completion of a treatment course.8

Anthony Fauci Develops Paxlovid Rebound

On June 28, Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID) and President Biden’s chief medical adviser, announced that he was experiencing COVID-19 rebound following treatment with Paxlovid. Dr. Fauci, who received two doses of Moderna/NIAID’s mRNA-1273 (also known as “Spikevax”) messenger RNA (mRNA) COVID shot plus two booster shots but still developed COVID last month, completed a treatment with Paxlovid.9 10 11 12

Dr. Fauci said that, after taking Paxlovid, he tested negative for SARS-CoV-2 for three consecutive days, but on the fourth day he tested positive for the virus. He said that, on the fifth day he “started to feel really poorly, much worse than in the first go-around.” Dr. Fauci referred to the relapse as “Paxlovid rebound.” Still, he decided to proceed with a second round of Paxlovid.9 10 11


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Click here to view References:

1 Hendler C. Paxlovid Users May Face Rebound SARS-CoV-2. The Vaccine Reaction May 30, 2022.
2 Thompson D. COVID Can ‘Rebound’ After Treatment With Paxlovid, CDC SaysU.S. News & World Report May 24, 2022.
3 U.S. Centers for Disease Control and Prevention. CDC Health Advisory. May 24, 2022.
4 Wehrwein P. Paxlovid Rebound: Rare But Real. Managed Healthcare Executive. June 14, 2022.
5 News Release. Coronavirus (COVID-19) Update: FDA Authorizes First Oral Antiviral for Treatment of COVID-19. U.S. Food and Drug Administration Dec. 22, 2021.
6 Wikipedia. Nirmatrelvir.
7 Wikipedia. Ritonavir.
8 U.S. Food and Drug Administration. FDA Updates on Paxlovid for Health Care Providers. May 4, 2022.
9 Farberov S. Dr. Fauci reveals ‘COVID rebound’ after Pfizer’s Paxlovid treatment. New York Post June 29, 2022.
10 Mitropoulos A. Fauci says he’s taking 2nd course of Paxlovid after experiencing rebound with the antiviral treatment. ABC News June 29, 2022.
11 Weixel N. Fauci says he is experiencing ‘rebound’ of COVID symptoms after Paxlovid treatment. The Hill June 29, 2022.
12 Cáceres M. More Vaccinated, Boosted U.S. Government Leaders Test Positive for Coronavirus. The Vaccine Reaction June 20, 2022.

8 Responses to "‘COVID-19 Rebound’ May Be Worse Than Initial COVID Illness"

  1. Tom   July 4, 2022 at 6:22 pm

    There is still no proof that covid exists.

    Reply
  2. Mary   July 4, 2022 at 7:36 pm

    I’ll stick with the Zelenko protocol. No regrets, no covid and no known side effects.

    Reply
  3. Brenda   July 5, 2022 at 1:37 am

    I don’t think I would take this drug that was developed by the same company that developed the jab. I wouldn’t trust it at all to help me. I think it would harm more than help. And I still don’t believe fauci has taken any jabs or boosters. I think it is all smoke and mirrors. I don’t think anyone in the government administration has taken any jabs.

    Reply
  4. Alexandra D Itzhaki   July 5, 2022 at 4:29 am

    I don’t believe Fauci took the vax or these pills, he knows they’re dangerous.

    Reply
  5. Kay   July 5, 2022 at 4:54 am

    Anthony Fauci is a criminal And is under some kind of mind control by his handlers. Why is he still talking? Why is anyone listening to that low life.

    Reply
  6. Ray Horvath   July 5, 2022 at 8:13 am

    Pretty please, someone tell me, how “covid” can be diagnosed?

    The CDC declared the PCR test useless last December, although it is still widely-used, even for “monkeypox” and for the “bird flu.”

    Reply
  7. Wren   July 5, 2022 at 7:12 pm

    I sure do hope the good Dr Mengele, I mean Fauci, doesn’t succumb to all those stellar things tested and highly effective approved pharmaceuticals he’s taking. It would be a shame to lose such a brilliant mind and caring human being.

    Reply
  8. Tom oNeill   July 6, 2022 at 11:46 am

    Paxlovid worked well for us and family. The Covid symptoms went away quickly..

    Reply

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