Will Coronavirus Mutations Delay COVID-19 Vaccines?

Will Coronavirus Mutations Delay COVID-19 Vaccines?

Story Highlights

  • Seven different coronaviruses have been shown to cause disease in human beings, including common ones that tend to cause transient respiratory infections often referred to as the “common cold,” and others that cause more serious illnesses such as SERS, MERS and the current COVID-19.
  • The virus that causes COVID-19 has been believed to be relatively stable with a low mutation rate, leading vaccine manufacturers to believe a long-lasting vaccine could be created quickly.
  • New research has shown a significant mutation with different immune characteristics has already occurred on a genome sequence sample from January 27th, suggesting that if mutations can occur at any time, creating a vaccine may not be simple or even feasible.

One of the issues vaccine manufacturers have with creating a vaccine against coronaviruses is that, like influenza viruses, they contain single strands of RNA. This viral type has a tendency to mutate, making it a challenge to create a vaccine that might remain relevant on an ongoing basis.1

According to the U.S. Centers for Disease Control and Prevention (CDC), seven coronaviruses have been identified as capable of causing human disease. The four most common are 229E, NL63, OC43 or HKU1, which generally cause mild and passing respiratory symptoms often referred to as the “common cold.”2 Others are MERS-CoV, the coronavirus responsible for Middle East Respiratory Syndrome (MERS), SARS-CoV, which causes severe acute respiratory syndrome (SARS) and, now, SARS-CoV-2, the virus that has caused the current pandemic, coronavirus disease 2019 (COVID-19).3

Genomic Stability Informs Vaccine Development

SARS-CoV-2 had been considered to be a relatively stable coronavirus with a low rate of mutation, persuading some scientists that an effective vaccine could be found quickly. Professor Stefano Menzo, a virologist at Ancona University Hospital observed in March 2020 that, “Our initial data show that this is a very stable RNA virus, with only five novel variants,” adding that, ”A virus with a stable genome is good news for vaccine development because it indicates that the effectiveness of vaccines could be more consistent, possibly over many years.”4

A ‘Significant’ COVID-19 Mutation Identified

Nevertheless, several mutations have already been reported. By mid-April, researchers from the University of Cambridge mapping how the virus has spread from the epicenter in Wuhan, China, stated the virus has mutated into three distinct strains. The first is “Strain A,” thought to be the original strain found in Wuhan; the second is “Strain B,” two mutations from A and responsible for most of the cases in Wuhan and East Asia; and the third is “Strain C,” offshoot of B and the strain responsible for most of the infections in Europe.5

In April, researchers in Australia and Taiwan also published an article analyzing the mutation dynamics of SARS CoV-2 and found a mutant, stating, “This represents the first report of a significant SARS-CoV-2 mutant and raises the alarm that the ongoing vaccine development may become futile in future epidemic if more mutations were identified.”6 7

For this study, which has not yet been peer reviewed, 106 complete or nearly complete genome sequences were obtained from NCBI databanks. The study material included 54 nucleotide sequences from the U.S., 35 from China, 3 from Spain, 1 from Australia, 2 each from Brazil and India, and 1 each from Finland, Italy, Nepal, South Korea and Sweden. In almost all cases, the samples were highly homogeneous, sharing over 99 percent of their identity. But on one of the samples from India, collected on January 27, the researchers identified a mutation that they believe would result in a weaker “receptor binding affinity” for human Angiotensin-Converting Enzyme 2 (ACE2).

ACE2 Provides the Gateway to COVID-19

A protein receptor primarily found on the surface of cells in the veins, kidneys and testes, but also—importantly for COVID-19—found in the lungs, kidneys and intestines,8 ACE2 is believed to provide the entryway that allows the spiky proteins on the SARS-CoV-2 virus to connect to, enter, and infect the cells of the body.9 Those spiky proteins on the SARS-CoV-2 virus, specifically an area on the spikes known as the receptor-binding domain, or RBD, where the mutation was found, attach to protein receptors on the ACE2. These spikes represent a primary research targets for developing vaccines, therapies and diagnostics for COVID-19,10 11 so mutations that affect their ability to infect the cell may have important repercussions for investigations into COVID-19.

Mutation Dynamics of COVID-19 Need Monitoring

Agreeing that SARS-CoV-2 has a much lower mutation rate than SARS, for example, the researchers warned:

Whilst it is generally safe to say that SARS-CoV-2 tends 
to mutate at a low rate, all current analyses are merely based on data collected at the early stage of this pandemic. As the 
virus continues to spread rapidly around the world, and more genomic data is accumulated, the evolution and mutation 
dynamics of SARS-CoV-2 still need to be monitored closely… the observation in this study raised the alarm that SARS- 
CoV-2 mutation with varied epitope profile could arise at any time, which means current vaccine development against 
SARS-CoV-2 is at great risk of becoming futile.12


References:

7 Responses to "Will Coronavirus Mutations Delay COVID-19 Vaccines?"

  1. DesertChick   May 4, 2020 at 3:18 pm

    Which is, no doubt, why they are making noises about a Big Jab with 6 (or More) in it. For the adventurous, this will really be a crap shoot on whether you can beat the side effects roulette wheel, will it not? And the extra excitement of a track-and-trace microchip will be too much for the thrill seekers to resist, right? Actually, the stupid. But then, that is obvious.

    Reply
  2. CAWS   May 4, 2020 at 3:49 pm

    Doesn’t matter to the manufacturers as long as we are forced to take it . They will make 93 BILLION, we will be sick,broke ,dying,chipped, freedom less and they will be exempt from prosecution. Great depopulation plan–stealth kill.

    Reply
  3. MICHAEL   May 4, 2020 at 4:38 pm

    BACK TO BASICS – ISN’T THIS VACCINE SURE TO USE ALUMINUM, MERCURY, OR BOTH? I READ IT WAS AN “RNA TYPE” VACCINE SO DOES THAT STILL REQUIRE THE METAL ADJUVANT/PRESERVATIVE OF CHOICE?

    Reply
  4. nathalie   May 5, 2020 at 11:14 am

    and how would having billion be worth anything when the economy is completely shot and human beings disabled or dead? I do not understand how short-sighted this all is.

    Reply
  5. Colorado   May 6, 2020 at 12:33 pm

    Where can one turn for intravenous vitamin C injections, on a state by state basis, where the practitioners of this legal service are not currently being railroaded and shut down by the medical industrial complex and their for hire government henchmen?

    We had such a peaceful and prosperous society until this corporate criminality got this far.

    We tried to stop it ahead of time, but few listened.

    Until such time as people cooking books, engaging in medical research fraud, and those arguing to limit Americans rights are incarcerated, this will continue.

    Bastiat: (in modern language); Sometimes the entire body of government, the courts, the safety guidance institutions, their corporate partners, the judges, the media, those whom enforce collections and compliance, sometimes they are all corrupt. And they paint the innocent man merely trying to defend his individual liberty, as the criminal.

    The cruel choice is here. When a citizen must either lose respect for the law or accept immorality as the law. These are impossible choices.

    Reply
  6. Linda C.   May 19, 2020 at 11:54 am

    Excellent information that is critical to the important analysis regarding the feasibility of a vaccine.

    I agree with the others who have commented here. We are facing an alarming and unsettling time. If immuno-therapy by vaccines is possible it makes sense to ramp up the immune system of earth-wide residents by accomplishing the very thing that was in place when measles had already dropped to near non-existence before the measles vaccine, good nutrition, good hygiene, good and clean water for cooking drinking and bathing. Why not make worldwide investments in these foundations for good health. Oh, yeah, no money in that for these massive corporations or the health organizations like the CDC who already own a litinany of vaccine patents. Money is driving this push for a vaccine, not good sense and obvious logic. It is scary…these are frightening times.

    Reply
  7. Colorado   May 21, 2020 at 4:12 pm

    Do not miss this video. A must watch! Vaccine mandates, vaccine safety, coronaphobia, pro interviews. Amazing, best watch of the year. The 10 reasons he’s off the coronaphobia train at the end is just packed full of solid factual information.

    https://www.youtube.com/watch?v=buDODwY72fM&feature=youtu.be

    Reply

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