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Moderna to Use New mRNA Technology to Develop Coronavirus Vaccine

vaccine researcher

Story Highlights

  • In light of the coronavirus outbreak, three research teams have been awarded grants by the Coalition for Epidemic Preparedness Innovations to develop a vaccine for the novel coronavirus.
  • In a public-private partnership with NIH, Moderna, Inc. is using an experimental mRNA technology to develop a vaccine.
  • Johnson & Johnson and other drug companies are shipping different drugs, such as HIV therapies, to China to treat coronavirus infected patients.

The recent outbreak of a novel coronavirus that originated in Wuhan, China has driven pharmaceutical and biotechnology companies to begin developing a vaccine for the mutated virus.

Three Companies Awarded Funding for Coronavirus Vaccine Development

Three research teams have received funding from the Coalition for Epidemic Preparedness Innovations (CEPI), a global public-private partnership launched at the Davos World Economic Forum in 2017, to develop a vaccine for the new strain of coronavirus (2019-nCoV).1

The first grant was awarded to Moderna, Inc., which has partnered with the National Institute of Allergy and Infectious Diseases (NIAID) within the National Institutes of Health (NIH) to develop a vaccine for the Wuhan strain of coronavirus.1 Some researchers believe that an experimental vaccine previously designed to combat severe acute respiratory syndrome (SARS), which was never licensed, as well as vaccine platforms using messenger RNA (mRNA) technology, which has not yet been approved by the FDA for vaccine production, are likely to shorten the time needed to fast track a 2019-nCoV vaccine to market.2

Andrew Pekosz, PhD, professor of molecular microbiology and immunology at Johns Hopkins University’s Bloomberg School of Public Health told MarketWatch, “There’s been some really good work on SARS and MERS that is educating this process.”2 He added:

You assume that everything that works for SARS and MERS will work for this virus, therefore you just plug in the very specific pieces of the new coronavirus into these vaccine platforms [and] you should be able to get vaccine candidates very quickly.2

Anthony Fauci, MD, director of NIAID said during an interview with the Journal of the American Medical Association (JAMA) he is confident that within three months or less, an experimental coronavirus vaccine will be in a Phase 1 clinical trial.2 Some experts say an emergency-use coronavirus vaccine could be ready within one year.2

The second CEPI grant was given to Inovio Pharmaceuticals, Inc. headquartered in Pennsylvania. The drug company received a grant of up to $9 million to develop a 2019-nCoV vaccine.3

The third CEPI grant was given to the University of Queensland in Australia. Paul Young, PhD, head the university’s school of chemistry and molecular biosciences, said the university has novel technology for the rapid generation of new vaccines using knowledge about a virus’s genetic sequence information.4

Moderna Developing Vaccine Based on mRNA Technology

On Jan. 23, 2020, Moderna announced that it “will manufacture an mRNA vaccine against 2019-nCoV, which will be funded by CEPI. The Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, collaborated with Moderna to design the vaccine. NIAID will conduct IND-enabling studies and a Phase 1 clinical study in the U.S.”5

Moderna is using a new technology known as Messenger RNA (mRNA) to develop a vaccine for the novel coronavirus. Moderna’s website states:

mRNA medicines aren’t small molecules, like traditional pharmaceuticals. And they aren’t traditional biologics (recombinant proteins and monoclonal antibodies) – which were the genesis of the biotech industry. Instead, mRNA medicines are sets of instructions. And these instructions direct cells in the body to make proteins to prevent or fight disease.6

What are RNA vaccines? Unlike a traditional vaccine, RNA vaccines introduce an mRNA sequence (the molecule which tells cells what to build), which is coded for a disease specific antigen. Once produced within the body, vaccine developers say the antigen is recognized by the immune system and stimulates a strong inflammatory response to produce antigens to fight the pathogen.7

Messenger RNA vaccines are faster and cheaper to produce than traditional vaccines and do not utilize any parts of the pathogenic virus or bacteria. Researchers believe that the lab production of messenger RNA vaccines will speed up new vaccine development and responses to disease outbreaks and epidemics, with the potential to scale and standardize the vaccine manufacturing process.6

In a scholarly article published in 2018 in Nature Reviews Drug Discovery, Norbert Pardi, PhD and his colleagues wrote that, while pre-clinical studies have shown optimism about the prospects of mRNA-based vaccines, two recent clinical reports revealed less than optimal vaccine effectiveness.. In both trials, immunogenicity was lower in humans than was expected based on animal models, a phenomenon also observed with DNA-based vaccines, and side effects experienced by participants were not trivial.8

According to Stephane Bansel, Moderna’s Chief Executive Officer:

Once we have managed to master the technology that works on humans, things could go very quickly because it is always the same manufacturing process … for messenger RNA against the flu or against the coronavirus, it is the same method of manufacturing, the only difference is the order of letters that code the proteins.9

Johnson & Johnson and Other Drug Makers to Ship Therapies to China

Johnson & Johnson is the latest pharmaceutical corporation to begin working on a vaccine for the new strain of coronavirus.10 Johnson & Johnson said its vaccine program would use the same technologies used to make its experimental Ebola vaccine, which is currently being administered in the Democratic Republic of Congo and Rwanda.9

Johnson & Johnson’s Chief Scientific Officer Paul Stoffels said Johnson & Johnson agreed to a recent request by Chinese health authorities to ship its HIV drug Prezcobix for potential treatment of coronavirus infections.11

Dr. Stoffels said, “Industry can take different steps to combating this epidemic as fast as possible.”10 He added that studying Prezcobix in patients who test positive for the coronavirus would not harm them, and could help authorities find a treatment that works.10

Merck & Co. has also assigned a team of scientists to assess whether any of the company’s drugs might be effective against the Wuhan coronavirus.10

Gilead Sciences, a biotechnology company based in California is having discussions with researchers and clinicians in the United States and China about using its experimental antiviral therapy, Remdesivir, to treat coronavirus patients. Remdesivir has not been licensed yet by the FDA for public use inside or outside the United States.10


1 Srikanth A. The US Is Racing to Develop a Coronavirus Vaccine. Jan. 28, 2020.
2 Lee J. Coronavirus update: Vaccine expected in Phase 1 trial within months, WHO to reconvene on Thursday. MarketWatch Jan. 29, 2020.
3 Streetwise Reports. Inovio Pharma Awarded $9M Development Grant for Coronavirus Vaccine. Street Wise Reports Jan. 27, 2020.
4 The University of Queensland. Race to develop coronavirus vaccine. The University of Queensland Jan. 24, 2020.
5  Moderna, Inc. Moderna Announces Funding Award from CEPI to Accelerate Development of Messenger RNA (mRNA) Vaccine Against Novel Coronavirus. BusinessWire Jan. 23, 2020.
6 Moderna, Inc. The Science and Fundamentals of mRNA Technology.
7 The PHG Foundation. RNA vaccines: an introduction.
8 Pardi N, et al. mRNA vaccines — a new era in vaccinology. Nature Reviews Drug Discovery 2018; 17(4): 261-279.
9 Channel News Asia. Wuhan coronavirus vaccine will take months: Biotech exec. Feb. 1, 2020.
10 Reuters. Johnson & Johnson working on vaccine for deadly coronavirus. Jan. 29, 2020.
11 Hopkins JS. U.S. Drugmakers Ship Therapies to China, Seeking to Treat Coronavirus. The Wall Street Journal Jan. 27, 2020.

7 Responses

  1. Using genetic sequences in vaccines without knowing how they work is monstrous. They have no idea what they’re unleasing and the general population are the guinea pigs.

  2. “He added that studying Prezcobix in patients who test positive for the coronavirus would not harm them, and could help authorities find a treatment that works.” Some of the side effects of Prezcobix include Hepatotoxicity, Immune Reconstitution Syndrome, Effects on serum creatinine, Severe skin reactions like toxic epidermal necrolysis….well, you get the idea. No harm done. Nothing like a nice captive(literally) audience to test out your drugs and vaccines on.

  3. A big Win-Win situation! So many different medical and pharmaceutical companies who want a piece of the manufactured Corona Pie!

  4. I’ve been reading Dr. Weiler series on the Coronavirus and there are indications that people being infected by this virus is because of previous vaccinations to the SARS virus years ago which has made them more susceptible to this new strain of Coronavirus. SARS is a Coronavirus. It’s complicated so you’d have to read all his articles on it but the jest is it’s not a Bioweapon as some have implied. Mandatory vaccination in China, SARS starting as far back as 2004 that included a spike protein. After sensitization by a vaccine against a form of Coronavirus, a rechallenge by another Coronavirus can lead to massive pneumonia, according to the research. Please read Dr. Weiler’s reports to put this into perspective.

    One way to think about this is the Flu study done by Dr. Danuta Skowronski of the British Columbia Centre for Disease Control study showed that repeated Flu shots made people more susceptible to the Flu in the future.

    Some interesting info:
    -China said it confirmed 15,152 new cases and 254 additional deaths and that those figures include the ones reported earlier by Hubei province.
    -China’s Hubei province reported an additional 242 deaths and 14,840 new cases as of Feb. 12.
    -The province said it is starting to include “clinically diagnosed” cases in its figures and that 13,332 of the new cases fall under that classification.

    Clinically Diagnosed:
    Diagnosis based on a study of the signs and symptoms of a disease.

    So if this is correct they (China) are no longer doing a TEST to determine if a person has the virus they are relying on symptoms & signs.

    NO tests for the presence of the coronavirus are now necessary, in China.

    The new method of counting? CT scans (computed tomography scans) of the chest.

    The scans are used to diagnose standard traditional lung diseases.

    For example, pneumonia.

    And pneumonia is called THE “coronavirus illness.”
    (video at link)

    “There is only one problem. Deaths from pneumonia, in China, appear to be 300,000 per year / 3 million per decade (I’m making a major downward estimate, based on correcting an error and referring to a trusted source.) These deaths certainly occurred in time periods before the purported emergence of the new coronavirus. Pneumonia has been around forever.”

    Get it? A test for ordinary pneumonia—CT Scan—now becomes a test that delivers a diagnosis of “new epidemic coronavirus.”

    Than there is this:
    The CDC sent novel coronavirus testing kits to Florida. They might not work
    Florida health officials received testing kits for novel coronavirus earlier this week but can’t use them yet because it’s unclear whether the tests are working.

    So, do we really know what is going on in China?

  5. “Gilead Sciences, a biotechnology company based in California is having discussions with researchers and clinicians in the United States and China about using its experimental antiviral therapy, Remdesivir, to treat coronavirus patients. Remdesivir has not been licensed yet by the FDA for public use inside or outside the United States.”

    Remdesivir……derivative of AZT (azidothymidine)……chemo treatment. DNA chain terminator. Kills bone marrow where white blood cells are made. Great idea. In much lesser dose now then when first released to treat HIV in late 80’s. 600mg/day+-, which killed thousands of AIDS patients, not the ghost HIV.

  6. It is a ‘rule’ in biowarfare that organisms are never released until a successful treatment or vaccine is available.

  7. From what I am reading, the primary result of the virus is ARDS (Acute respiratory distress syndrome) which is a little different from plain old pneumonia. But you make some good points and no, I don’t think there is any way to really know what’s going on in China. But now it is spreading to Italy, so maybe we will learn more.

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