Public Acceptance of COVID-19 Vaccine Faces Many Hurdles

Public Acceptance of COVID-19 Vaccine Faces Many Hurdles

Story Highlights

  • Even before a vaccine against COVID-19 has been introduced to the public in the U.S., expectations for it are low.
  • Dr. Anthony Fauci warns that a COVID-19 vaccine is not expected to be either long-lasting or more than 50 to 60 percent effective.
  • Citing experience with other vaccines, a COVID-19 vaccine is not expected to provide much, if any, benefit for obese patients, defined as those with a greater than 30 percent body mass index (BMI), which includes approximately 42 percent of adults in the U.S.

Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases since 1984 has said chances are slim that early vaccines against COVID-19 will be “highly effective,” defined as having a 98 percent effectiveness rating.1 Instead, Fauci predicts that an effectiveness of 60 percent or less is about the best that might be expected, adding that a vaccine with even 50 percent effectiveness would probably be considered acceptable and given the “green light” by the FDA.2

Fauci has also said that, if COVID-19 acts like other coronaviruses, vaccination may not provide durable protection. In a live stream videoconference, he said: “You can assume, that you’re going to get protection at least to take us through this cycle. When you look at natural infection it’s anywhere from six months to a year. However, with this spike protein that’s being presented in the way that we do it, with primes and in some cases boosts, we’re going to assume that there’s a degree of protection, but we have to assume that it’s going to be finite.”3

Low Expectations for Early COVID-19 Vaccines

Adults and people with co-existing chronic conditions, such as diabetes or heart disease, as well as those who are obese or live with chronic stress, are recognized as being at higher risk for complications from SARS-Cov-2 infections. Many of these same chronic poor health conditions also are predictive of adverse responses to vaccines in general. Older age, for example, is known to be associated with a less robust immune response to both vaccination and natural infection.4 Gender, genetics, blood type and underlying conditions such as diabetes mellitus, all of which have been associated with more severe COVID-19 infection outcomes, have been found to influence individual immune responses to certain vaccines, although significant variations are reported.5

COVID-19 vaccines are not expected to provide much, if any, benefit for the more than 107 million people in the U.S. classified as obese.6 It has previously been recognized that vaccines are not as effective in obese people compared to the general public.7 According to Raz Shaikh, associate professor of nutrition at the University of North Carolina-Chapel Hill, there is no reason to think a COVID-19 vaccine will be any different. He said: “Will we have a COVID vaccine next year tailored to the obese? No way… Will it still work in the obese? Our prediction is no.”8

The Role of Obesity in Vaccine Responses

Early warnings about the increased COVID-19 infection risks faced by the obese in the pandemic came from China, where it was reported that patients with a higher body mass index (BMI) were significantly more likely to become critically ill or die from their illness compared with the general patient population.9 The first reports from the Centers for Disease Control and Prevention (CDC) indicated that patients considered “morbidly obese,” defined as those with a BMI of 40 or more, or 100 pounds over recommended weight, were at highest risk for developing severe coronavirus symptoms.

About nine percent of the U.S. population falls into the morbidly obese category. As the picture of which patients were most severely affected by COVID-19 became clearer, however, the warning has been expanded to include those at a BMI of 30 and above, or 42.4 percent of adults in the U.S.

Researchers are not sure why obesity seems to have such an impact on immune response and response to vaccination but mechanisms involving chronic inflammation may be responsible. Inflammation is a normal response to infection (or vaccination). After the immune system’s inflammatory response to the perceived threat posed by infection or vaccination is mounted, normally the inflammation ceases and health returns. However, in obese people and those with related risk factors, such as high blood pressure or elevated blood sugar levels, the inflammatory response does not “turn off” and progresses to a state of chronic mild inflammation.10

Others have suggested that the standard 1” needle may not be adequate to reach muscle tissue. It has been speculated that those with a higher BMI may require larger doses of vaccine product.11

Hepatitis B and Influenza Vaccines and Obesity

Early evidence of the effect of obesity on response to vaccination was reported in a 1985 study of hundreds of hospital workers vaccinated against hepatitis B. In that study, the hepatitis B vaccine was half as likely to protect against hepatitis B in those with a higher BMI compared to their co-workers with lower BMIs. Even when the trial was repeated with longer needles to ensure the vaccine was injected into muscle tissue rather than adipose tissue (fat), the results were the same.

A 2017 study showing that even though obese patients vaccinated against influenza did produce “a protective level of antibodies to the influenza vaccine,” they were still twice as likely as non-obese adults of a healthy weight to develop influenza or flu-like illness, at 9.8 and 5.1 percent, respectively. Those authors concluded that, “the current standard for correlates of protection, suggesting use of antibody titers to determine vaccine effectiveness in an obese population may provide misleading information.”12

Obese patients have commonly been excluded from clinical trials on experimental drugs and vaccines due to concerns that co-morbidities frequently associated with obesity might cloud results. COVID-19 safety and efficacy trials currently underway do not exclude people with obesity. Although obesity is not being viewed as a specific potential complication at this point, BMI for study participants will be reported and evaluated.13

Rapid COVID-19 Vaccine Approval Sparks Concerns

With a stated goal of delivering “300 million doses of a safe, effective vaccine for COVID-19 by January 2021, as part of a broader strategy to accelerate the development, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics (collectively known as countermeasures),” operation “Warp Speed” has already streamlined procedures ordinarily in place to test the safety and efficacy of vaccines over the course of years.14 The Warp Speed plan states that no corners will be cut that would compromise the safety of the proposed vaccines, even though clinical trial steps are being taken simultaneously rather than consecutively as is done in non-emergency circumstances.

For example, the most promising vaccine candidates are being manufactured “at industrial scale” even before the studies are completed to establish vaccine efficacy and safety as happens normally. Theoretically, this strategy supposedly increases financial risk for companies but does not increase product risks.

Francis Collins, MD of the National Institutes of Health (NIH) has said:

I think this is an effort to try to achieve efficiencies, but not to sacrifice rigor… Definitely the worst thing that could happen is if we rush through a vaccine that turns out to have significant side effects [The NIH] is creating a master plan for testing the leading COVID-19 vaccine candidates in tens of thousands of people, to prove whether they really work and if they’re safe.

Addressing Russia’s newly approved vaccine, “Sputnik V,” scientists and public health professionals have expressed concern that the Russian vaccine still needs critical safety and efficacy studies, and they worry that the hasty introduction of that vaccine could put pressure on the U.S. to prematurely approve a COVID-19 vaccine of its own.15

Only about half of Americans plan to get the COVID-19 vaccine if it becomes available, with 7 in 10 of those who plan to refuse citing concerns about safety issues surrounding the rushed approval process to fast track a vaccine to licensure.16


References:

1 Lovelace B, Higgins-Dunn N. Dr. Anthony Fauci Says Chance Of Coronavirus Vaccine Being Highly Effective Is ‘Not Great’. CNBC Aug. 7, 2020.
2 Heisler Y. Dr. Fauci Just Gave Us Some Pretty Scary News About Coronavirus Vaccines. BGR Aug. 9, 2020.
3 Kollmeyer B. Fauci Warns That COVID-19 Vaccine Protection May Be ‘Finite’. MarketWatch July 7, 2020.
4 Lord JM. The Effect Of Aging Of The Immune System On Vaccination Responses. Hum Vaccin Immunother June 1, 2013.
5 Zimmermann P, Curtis N. Factors That Influence the Immune Response to Vaccination. American Society for Microbiology.
6 Varney S. America’s Obesity Epidemic Threatens Effectiveness of Any COVID Vaccine. Kaiser Health News Aug. 6, 2020.
7 Meek A. Bad News: Scientists Think A Coronavirus Vaccine Might Not Work For One Huge Group Of People. BGR Aug. 9, 2020.
8 See Footnote 6.
9 Peng YG, et al. [Clinical Characteristics And Outcomes Of 112 Cardiovascular Disease Patients Infected By 2019-Ncov]. Pub Med Mar. 2, 2020.
10 See Footnote 6.
11 Wood N. COVID-19 Vaccine May Be Less Effective In Obese People, Experts Warn. ABC News Aug. 12, 2020.
12 Neidich SD, et al. Increased Risk Of Influenza Among Vaccinated Adults Who Are Obese. Int J Obes (Lond) September 2017.
13 See Footnote 6.
14 Fact Sheet: Explaining Operation Warp Speed. Department of Health and Human Services Aug. 7, 2020.
15 Lovelace B. Trump On Russia’s Approved ‘Sputnik V’ Coronavirus Vaccine: ‘We Hope It Works’. CNBC Aug. 14, 2020.
16 The Associated Press. Only Half Of Americans Would Get A COVID-19 Vaccine, Poll Shows. CBS News May 27, 2020.

9 Responses to "Public Acceptance of COVID-19 Vaccine Faces Many Hurdles"

  1. Brian James   August 25, 2020 at 2:13 pm

    Jul 16, 2020 TRUTH With Robert F. Kennedy, Jr., Episode 8

    Polly Tommey covered a wide range of topics including Dr. Fauci’s failures and dialed-back vaccine promises, toxic vaccine adjuvants, Bill Gates’ GAVI and loss of individual freedom, annual flu death exaggerations and more.

    https://youtu.be/rJjol_-6yPc

    Reply
  2. Kaitlyn Y.   August 25, 2020 at 4:21 pm

    I really wish the issue of whether a virus has ever been properly purified, isolated, and proven to cause any illness would be addressed here. When looking into this, I have found no credible studies proving viruses exist, much less causing any illness. If this is the case, what are the vaccines for at all? I think terrain theory better explains how we get ill. But, that doesn’t sell any drugs or vaccines! Food for thought……..

    Reply
  3. Tom   August 25, 2020 at 6:44 pm

    Whatever substitutes as a vaccine will not be to stop Covid. When it takes 5-10 years and sometimes longer to make a vaccine, you have to wonder about doing it in under a year. It is highly possible that this virus, although I do not believe it is a true coronavirsus, will change into something else and thus a vaccine will be chasing a ghost. There are at least 7 coronaviruses and no vaccine has ever been adopted. After hearing about the vaccine Moderna is making, it is not a vaccine at all but an RDA/DNA altering drug with God knows what mixed in. The name Mode-rna…modified RNA says it all. NO THANKS…ever. I don’t care how many experiments they do on humans, it won’t be good.

    Reply
  4. Nick Quinlan   August 25, 2020 at 6:44 pm

    Everyone considering taking the Moderna covid vaccine should watch this 20 minute video, its quite eye opening.
    There is a reason they demand everyone on earth gets vaccinated with these vaccines, and its not good.
    https://www.bitchute.com/video/Ofm3QnUjcIJT/

    Reply
  5. George   August 25, 2020 at 7:58 pm

    Toni Fauci and his NIH gave $3,7 million to the Wuhan Institute of Virology to continue gain of function research after it wes deemed too dangerous to continue at The University of North Carolina. He, along with many others are guilty of mass murder and crimes against humanity.

    Reply
  6. Nancy Allen   August 26, 2020 at 11:47 pm

    George, and the ‘guilt’s Fauci, NIH,CDC, FDA leadership extends beyond the financially gain of function research that is well documented in published research. The hydroxchloroquine protocol is safe and effective. The so called studies republished in Lancet and NEJM used made up data from Sursiphere – a totally frraudulent company.

    Yet Fauci and others declared that these 2 journal articles proved that HCQ was not effective and even dangerous. Of course, the articles were withdrawn, but continued to be flashed on Google searches.

    Research back to at least 2005/2010 has shown that chloroquine/HCQ were effective in inhibiting the growth of SARS-CoV viruses in living cells :
    1. Vincent MJ et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virology Journal 2005; 2:69
    2. Aartjian JW et al. Zn=2 inhibits Coronavirus and Arterivirus RNA Polymerase Activity IN VITRO and zinc ionophores block the replication of these viruses in cell culture. PLOS PATHOGENS; Nov.4,2010. And there is so much more published by other countries on the current effectiveness of HCQ + zinc + azithromycin.
    3. In 2016 the WHO had a special meeting in Geneva, The Cardiotoxicity of antimalarials. Their extensive report is summarized, ” Apart from halofantrine, antimalarial medicines that prolong the QT/QTc interval, such as chloroquine . . . have been associated with a low risk of cardiotoxicity. Drug-induced TdP and life-threatening ventricular tachyarrhythmias are very rare events.” So, HCQ is safe.

    The point is, I knew of this research, certainly Fauci knew of this research. And yet the use of HCQ was blocked in many states. How many died because they did not have access ?? Yes, we need a class action suit by those families whose loved ones were told to just wait and see, and did not have any treatment at first sign of illness, then later died. This is manslaughter at the least.

    Reply
  7. Brian James   September 4, 2020 at 8:53 pm

    September 4, 2020 UN Says New Polio Outbreak in Sudan Caused by Oral Vaccine

    The World Health Organization says a new polio outbreak in Sudan is linked to an ongoing vaccine-sparked epidemic in Chad — a week after the U.N. health agency declared the African continent free of the wild polio virus.

    https://apnews.com/619efb65b9eeec5650f011b960a152e9

    Reply
    • Shadow   September 13, 2020 at 10:41 am

      Those vaccines came from Bill Gates. The Polio they are now chasing, all come from the vaccines. All his vaccines are dangerous. In India almost 500,000 children, were Paralyzed. India kicked him out and are now taking him to court. Gates likes to experiment on kids in third world countries. That is just the tip of his iceberg. His crimes against humanity run very deep. Now he wants to experiment on the entire world. Knowing what many of us know everyone really needs to say No to the vaccines. Add to that the companies making the vaccines, cannot be sued for damages the vaccines will do. So if they kill or maim us, to bad so sad. I am not sure who is worse Gates or the WHO. Both are just drug pushers. Gate bought WHO a long time ago. WHO is now just a corrupt organization, that needs to be dismantled. They work for the drug companies. That has been obvious for years. Some information on Tedros Adhanom is down a bit in the story. https://rainbowwarrior2005.wordpress.com/2020/09/05/__trashed/

      Reply
      • Kystel   September 29, 2020 at 1:34 pm

        Excellent link — thanks for sharing.
        Read a column in the Epoch Times that if Biden is elected he’ll require everyone get the COVID-19 vaccine.

        Reply

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